Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
To the best of our knowledge, this is the first report showing the possible association between P15(INK4B) promoter methylation and parvovirus B19 infection in acute leukemia.
|
18384396 |
2009 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that inactivation of p16 and p15 genes is one of the most common genetic events in acute leukemia, and plays an important role for the RB/p16 pathway in the pathogenesis of acute leukemia.
|
10634644 |
2000 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results demonstrate that CDK4I gene deletions are very frequent and probably early events in childhood acute leukaemias of lymphoid origin and especially in early-T and pre-B ALLs.
|
8555068 |
1995 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data show that inactivation of either the p15 or p16 gene by point mutation is a very uncommon event in acute leukaemias.
|
8616035 |
1996 |
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The frequency of p15(INK4B) gene methylation in newly diagnosed or relapsed AL was significantly higher than that in AL in the remission stage (P = 0.002) p15(INK4B) gene methylation was found in 5 of 13 (38%) low-risk MDS (RA/RAS) patients and 80% of them showed only partial methylation.
|
12150726 |
2002 |
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The entire CpG island region of p15 was largely devoid of methylation in normal lymphocytes, but methylation of varying density was found in primary acute leukemia.
|
10498617 |
1999 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Reports on homozygous deletion of p16 and p15 genes suggest the value of larger, prospective studies with standardized treatment protocols to definitively establish the prognostic utility of p15/p16 deletions in acute leukemias.
|
10073286 |
1999 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prognostic impact of p15 gene aberrations in acute leukemia.
|
27401303 |
2017 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that alterations of p16 and p15 genes are involved in a subset of acute leukemias with MLL gene rearrangement not only of lymphoid but also of myeloid phenotype.
|
9447829 |
1997 |
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, the authors investigated the frequency and prognostic significance of p15 and p16 gene methylation in adult acute leukemia.
|
11413509 |
2001 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hypermethylation of CpG islands in the promoter region of the p15INK4B gene in childhood acute leukaemia.
|
15737564 |
2005 |
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Cyclin-dependent kinase inhibitor p15 is frequently inactivated by either methylation or deletion in patients with acute leukemia.
|
15755508 |
2005 |
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications.
|
10706859 |
2000 |